ACH病因明确，由FGFR3基因的功能获得性突变导致。该基因调控骨骺生长板软骨细胞增殖分化的重要负调节因子，当其持续激活时，长骨生长被抑制，最终形成特征性的四肢短小身材。
Grammar and flow could use improvement
，更多细节参见搜狗输入法2026
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particularly surprised by the outcome, the 2984 was always a "request quotation"
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